In the phase 3 OPTIMA trial, the 10-mg/kg and 3-mg/kg doses reduced new heterotopic ossification lesions by 90% and 94%, respectively, compared with placebo at 56 weeks.
A structured overview of recent FDA recalls, corrections, and alerts involving medications, ventilators, insulin delivery systems, cardiovascular devices, anesthesia products, and other equipment used in clinical practice.
In a randomized clinical trial of patients at increased risk for persistent symptoms, clinician-supported biopsychosocial self-management was associated with lower pain impact and fewer chronic pain outcomes than guideline-based medical care.