Clinical Report: CKM Staging Faces an Early Vascular Test
Overview
A cross-sectional study involving 1,283 young adults found that more advanced stages of cardiovascular-kidney-metabolic syndrome (CKM) were linked to lower cardiovascular health scores and increased early carotid arterial injury.
Background
Understanding the relationship between cardiovascular health and CKM syndrome is crucial, especially as these conditions can significantly impact long-term health outcomes.
Data Highlights
| CKM Stage | Percentage of Participants | Mean Life’s Essential 8 Score | Mean-Maximum Carotid Intima-Medial Thickness (mm) |
|---|---|---|---|
| Stage 0 | 21% | 78 | - |
| Stage 1 | 40% | 70 | 0.014 higher than Stage 0 |
| Stage 2 | 36% | 64 | 0.020 higher than Stage 0 |
| Stage 3 | 3% | 64 | 0.100 higher than Stage 0 |
Key Findings
- Participants were classified into CKM stages with 21% at stage 0, 40% at stage 1, 36% at stage 2, and 3% at stage 3.
- Adjusted mean Life’s Essential 8 scores decreased from 78 in stage 0 to 64 in stages 2 and 3.
- More advanced CKM stages correlated with higher mean-maximum carotid intima-medial thickness.
- Mean-maximum carotid intima-medial thickness was 0.100 mm higher in stage 3 compared to stage 0.
- Scores for health-behavior components did not differ statistically across CKM stages, possibly due to limitations in self-reported data.
- The study highlights the association of CKM stages with early markers of carotid arterial injury in young adults.
Clinical Implications
The findings indicate that young adults with advanced CKM stages may be at increased risk for cardiovascular issues.
Conclusion
This study highlights the association of CKM staging with early cardiovascular risk factors among young adults.
Related Resources & Content
- Vaishnavi Krishnan, Circulation: Population Health and Outcomes, 2023 -- CKM Staging Faces an Early Vascular Test
- MDSpire News — Optimizing Nodal Staging for Early Metastasis Detection in cSCC
- Frontiers in Immunology — Creation and Clinical Use of an Automated Local Kidney Allocation System Incorporating Virtual Crossmatch
- Pediatric Cardiology — Evaluating the Diagnostic Role of 99mTc-MIBI Myocardial Perfusion Imaging for Identifying Myocardial Ischemia in Pediatric Patients with Kawasaki Disease and Coronary Artery Abnormalities
- Frontiers in Oncology — Case Report: Superficial Kaposiform Hemangioendothelioma Without the Kasabach–Merritt Phenomenon
- 2026 AHA/ACC/ADA/ASN Guideline for the Prevention, Detection, Evaluation, and Management of Cardiovascular-Kidney-Metabolic Syndrome
- 2026 AHA/ACC/ADA/ASN Guideline for the Prevention, Detection, Evaluation, and Management of Cardiovascular-Kidney-Metabolic Syndrome: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines
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