5 Key Takeaways

• 1

  Oral antihistamines may not significantly improve disease severity or itch in atopic dermatitis patients.

• 2

  First-generation H1 antihistamines likely increase cognitive impairment and treatment discontinuation due to adverse events.

• 3

  Second-generation H1 antihistamines showed minimal reductions in objective Scoring Atopic Dermatitis scores compared to placebo.

• 4

  No clinically important difference was found for sleep disturbance or atopic dermatitis exacerbations with antihistamine use.

• 5

  The systematic review included 47 trials with 6,230 patients and assessed treatment effects using Bayesian random-effects network meta-analyses.