Clinical Report: Fatigue in Stage B Heart Failure May Signal Progression Risk
Overview
General and exertional fatigue are linked to poorer quality of life and increased risk of clinical heart failure in older adults with stage B heart failure. The study analyzed data from 2,972 participants over a median follow-up of 8.4 years, revealing significant associations between fatigue levels and heart failure events.
Background
Stage B heart failure is characterized by structural heart disease without clinical symptoms. Understanding the implications of fatigue in this population is crucial.
Data Highlights
| Fatigue Category | Incidence Rate (events per 1,000 person-years) |
|---|---|
| Low or No Fatigue | 12 |
| High General Fatigue Only | Data not specified |
| High Exertional Fatigue Only | Data not specified |
| Both High General and High Exertional Fatigue | 28 |
Key Findings
- 71% of participants reported low or no fatigue, while 29% had varying levels of fatigue.
- Participants with both general and exertional fatigue had the lowest physical and mental quality-of-life scores.
- High exertional fatigue was independently associated with incident clinical heart failure.
- All fatigue categories were linked to lower quality-of-life scores compared to low-fatigue participants.
- 338 new clinical heart failure events were documented during the follow-up period.
- Competing-risks regression indicated that all fatigue categories were associated with heart failure with preserved ejection fraction.
Clinical Implications
Healthcare providers should assess fatigue levels in patients with stage B heart failure as it may indicate a risk for progression to clinical heart failure. Early identification of fatigue can facilitate timely interventions to improve patient outcomes.
Conclusion
The study highlights the importance of monitoring fatigue in stage B heart failure patients, as it is associated with both quality of life and the risk of developing clinical heart failure.
Related Resources & Content
- Pavlovic N., et al., Atherosclerosis Risk in Communities Study, 2023 -- Fatigue in Stage B Heart Failure May Signal Progression Risk
- MDSpire News — Sudden Death Trajectories in HFpEF, HFmrEF
- JAMA Cardiology — Biomarker, Functional Status, and Quality-of-Life Trajectories Before Modes of Death in Heart Failure: Post
- baptist health south florida — Recognizing the Transition to Advanced Heart Failure Earlier
- Journal of Cardiac Failure — Circulating Proteomic Profiles in Ambulatory Patients With Advanced Stage C2D Heart Failure: Insights From the Registry Evaluation of Vital Information for VADs in Ambulatory Life (REVIVAL) Registry
- Sudden Death Trajectories in HFpEF, HFmrEF
- Biomarker, Functional Status, and Quality-of-Life Trajectories Before Modes of Death in Heart Failure: Post
- Recognizing the Transition to Advanced Heart Failure Earlier
- Second Universal Definition of Heart Failure
- 2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure
- Imaging and Cardiac Biomarker Associations With Preclinical Heart Failure Stage B to C Progression | JACC: Advances
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