5 Key Takeaways

• 1

  Accelerated biological aging may increase the risk of early-onset cancers, particularly among more recent birth cohorts.

• 2

  In the UK Biobank, patients born between 1965 and 1974 had a 23% higher PhenoAge-defined age gap than those born between 1950 and 1954.

• 3

  Each 1-standard deviation increase in PhenoAge-defined age gap was linked to an 8% higher likelihood of early-onset solid cancer.

• 4

  Organ-specific aging was associated with early-onset lung and colorectal cancers, independent of systemic aging measures.

• 5

  The study's observational nature limits causal conclusions, and findings may not generalize beyond UK and US populations.