5 Key Takeaways

• 1

  Post-orgasmic illness syndrome (POIS) causes fatigue, flu-like symptoms, and neuropsychiatric changes after orgasm.

• 2

  A narrative review suggests POIS may involve a multisystem inflammatory response rather than simple histamine intolerance.

• 3

  88% of men with POIS in a study had a positive skin response to their own semen, but this does not explain all cases.

• 4

  Treatment options for POIS include antihistamines, corticosteroids, and omalizumab, which has shown promising results.

• 5

  Further controlled studies are needed to understand POIS biology and treatment responses.