Objective:
To investigate the association between high consumption of sugar-sweetened beverages (SSBs) and the risk of oral cavity cancer (OCC) in female patients.
Approach:
- Study Design: A longitudinal cohort study analyzing data from 162,602 female patients in the Nurses' Health Study (NHS) and NHS II over 30 years.
- Participants: The study documented 124 invasive OCC cases among participants.
- Risk Assessment: Comparison of OCC risk between daily SSB consumers and those consuming less than one SSB monthly.
- Adjustment for Confounders: Multivariable-adjusted models accounted for age, caloric intake, tobacco use, alcohol consumption, body mass index, and glycemic load.
Key Findings:
- Daily SSB consumers had a nearly five times higher risk of developing OCC compared to those consuming less than one SSB monthly.
- The risk was 5.46 times higher among nonsmokers or light smokers and nondrinkers or light drinkers who consumed SSBs daily.
- The absolute baseline risk increase was low, with only 3 additional cases per 100,000 population.
Interpretation:
The study addresses a knowledge gap regarding OCC etiology in nonsmokers, particularly among White female patients, and suggests potential mechanisms linking SSB consumption to OCC.
Limitations:
- Precision of estimates may be affected by the small number of OCC cases.
- The cohort consisted exclusively of females and predominantly individuals of European descent.
- Further studies are needed in larger cohorts, including males.
Conclusion:
The authors concluded that additional studies are necessary to validate these findings.
Sources:
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