5 Key Takeaways

• 1

  Full-pressure external counterpulsation (ECP) showed greater cognitive and daily living improvements than low-pressure treatment in mild Alzheimer disease patients.

• 2

  The study involved 190 patients aged 55 to 85, diagnosed with mild cognitive impairment or mild Alzheimer disease, over a 12-month period.

• 3

  The primary efficacy outcome, the VADAS-cog score, improved by 9.95 points in the full-pressure group compared to 5.22 points in the low-pressure group.

• 4

  Adverse events were mostly mild skin irritations, with no serious events reported, and no brain edema or hemorrhage identified on follow-up imaging.

• 5

  The findings suggest further investigation of ECP in early Alzheimer disease, but do not establish its role alongside established therapies.