5 Key Takeaways

• 1

  Chlamydia pneumoniae and SARS-CoV-2 may contribute to Alzheimer's disease pathogenesis through neuroinflammatory pathways.

• 2

  The study reviewed existing research linking these infections to neurodegeneration and emphasized genetic risk factors.

• 3

  Both pathogens can infect the neuroepithelium of the olfactory system, providing a direct route to the brain.

• 4

  Infection by either organism can lead to elevated levels of IL-6 and CCL2 cytokines, contributing to Alzheimer's disease.

• 5

  The presence of the APOEε4 allele increases susceptibility to infections by Chlamydia pneumoniae and SARS-CoV-2.