Clinical Report: Who develops dementia after 90?
Overview
Dementia developed in approximately 17% of patients aged 90 years or older during a mean follow-up of 2 years in the LifeAfter90 cohort study. The study identified significant disparities in dementia incidence based on gender and race.
Background
Understanding dementia incidence in the oldest populations is crucial as the number of individuals aged 90 and older continues to rise. The LifeAfter90 study provides insights into dementia development in this demographic.
Data Highlights
| Characteristic | Value |
|---|---|
| Age-standardized dementia incidence rate | 117 cases per 1,000 person-years |
| Female incidence rate | 145 cases per 1,000 person-years |
| Male incidence rate | 80 cases per 1,000 person-years |
| Hispanic or Latinx incidence rate | 155 cases per 1,000 person-years |
| APOE epsilon 4 carriers incidence rate | 249 cases per 1,000 person-years |
Key Findings
- Dementia incidence was 17% among participants aged 90 years or older over a mean follow-up of 2 years.
- Female participants had a higher age-standardized incidence rate of 145 cases per 1,000 person-years compared to 80 among males.
- Hispanic or Latinx participants exhibited the highest incidence rate at 155 cases per 1,000 person-years.
- Black participants had a 75% higher dementia risk compared to Asian participants.
- APOE epsilon 4 carriers had a higher incidence rate of 249 cases per 1,000 person-years, although this was not statistically significant.
Clinical Implications
The findings suggest that gender and racial disparities exist in dementia risk among the oldest populations. Clinicians should consider these factors when assessing dementia risk and developing care plans for elderly patients.
Conclusion
The LifeAfter90 study reports the incidence of dementia in individuals aged 90 and older.
Related Resources & Content
- Colbeth HL, et al., The Lancet Healthy Longevity, 2023 -- Who develops dementia after 90?
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- Neuropathology in a diverse cohort of oldest-old: The LifeAfter90 study - PubMed
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