5 Key Takeaways

• 1

  Menopausal women with cognitive decline showed improvements in cognitive symptoms after 12 months of estriol-based hormone treatment.

• 2

  The study involved 20 menopausal women with a mean age of 53.5 years receiving daily oral estriol and progesterone as needed.

• 3

  Cognitive symptoms were assessed using the Voskuhl Menopause Brain Fog Assessment, revealing significant improvements across all cognitive domains.

• 4

  Preclinical assessments in mice indicated that estriol treatment reduced cognitive deficits and glial activation, suggesting a potential mechanism of action.

• 5

  The study's limitations include a small sample size, lack of randomization, and reliance on self-reported cognitive changes.