Investigators identified 2 histamine-related genes associated with keratoconjunctivitis sicca and found that suppressing either gene reduced inflammatory injury in corneal epithelial cells.
This article reviews practical strategies to reduce contact lens dropout by addressing the 5 most common contributors: lens discomfort, dry eye/ocular surface disease, visual performance, lens handling, and financial or lifestyle factors.
The phase 3 PREDICT-1 trial is evaluating licaminlimab in patients with dry eye disease, with a primary analysis focused on a genetically defined subgroup.