5 Key Takeaways

• 1

  A cohort study of 29,849 participants aged ≥60 identified frailty trajectories preceding dementia onset.

• 2

  Frailty, measured by a frailty index score, accelerated significantly 4-9 years before dementia diagnosis.

• 3

  Higher frailty levels correlated with increased dementia risk, with adjusted hazard ratios varying by cohort.

• 4

  Frailty scores began diverging between dementia and non-dementia participants 8-20 years before onset.

• 5

  Females had higher frailty index scores than males in the pre-dementia period, averaging 16.2%-20.9%.