Fibrinogen cryptokines may promote steroid-resistant asthma
Overview
This study investigates the role of fibrinogen cleavage products, or cryptokines, in glucocorticoid-resistant airway hyperresponsiveness (AHR) in preclinical models. Findings indicate that exposure to fungal elements and low-dose lipopolysaccharide (LPS) exacerbates AHR despite glucocorticoid treatment.
Background
Asthma is a chronic inflammatory disorder characterized by airway hyperresponsiveness and is often treated with glucocorticoids. However, some patients exhibit resistance to these treatments, necessitating exploration of alternative mechanisms contributing to this phenomenon. This study examines the role of fibrinogen cryptokines in steroid resistance.
Data Highlights
No numerical data or trial data presented in the source material.
Key Findings
- Fibrinogen cryptokines contribute to glucocorticoid-resistant AHR through TLR4 signaling.
- Fluticasone did not suppress AHR induced by Aspergillus niger in murine models.
- Low-dose LPS altered the inflammatory response and enhanced AHR in mice exposed to A niger.
- Glucocorticoid treatment did not reverse AHR in mice exposed to both A niger and low-dose LPS.
- Primary human sinonasal epithelial cells secreted fibrinogen and prothrombin, with cryptokine exposure significantly increasing their secretion.
Clinical Implications
Further investigation into the role of fibrinogen cryptokines is warranted.
Conclusion
The study highlights the role of fibrinogen cryptokines in promoting steroid resistance in asthma.
Related Resources & Content
- Y. Zeng et al., Mucosal Immunology, 2023 -- Fibrinogen cryptokines may promote steroid-resistant asthma
- Frontiers in Medicine — Fibrinogen-like protein 2 regulates inflammatory and metabolic reprogramming of airway smooth muscle cells through PI3K/Akt activation
- Frontiers in Endocrinology — Bone health in asthma: a twofold effect of disease and pharmacotherapy
- Intensive Care Medicine — Glucocorticoids Suppress Type I Interferon Beta Signaling and CD73 Expression in Human Lung Tissue
- Frontiers in Immunology — Necroptosis in asthma: a critical driver of immune dysregulation and airway remodeling
- Global Initiative for Asthma 2026 Strategy
- ISHAM-ABPA Working Group Guidelines
- Randomized Controlled Trial of Oral Antifungal Treatment for Severe Asthma with Fungal Sensitization | American Journal of Respiratory and Critical Care Medicine | Oxford Academic
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