In the phase 3 OPTIMA trial, the 10-mg/kg and 3-mg/kg doses reduced new heterotopic ossification lesions by 90% and 94%, respectively, compared with placebo at 56 weeks.
A case report highlighted extensive intratendinous urate deposition and bilateral Achilles tendon rupture, raising awareness of tendon complications in advanced gout.
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Joint tenderness showed broader associations with concurrent ultrasound abnormalities than patient-reported pain among anti-cyclic citrullinated peptide–positive patients without clinical arthritis.
In a single-center retrospective study, an internally validated model using radiologist-assessed imaging features and clinical data showed moderate discrimination of arthroscopic meniscal repairability.