Clinical Report: Do maternal SARDs relate to child mental health?
Overview
Maternal systemic autoimmune rheumatic diseases (SARDs) were linked to a higher incidence of childhood mental disorders, including anxiety and neurodevelopmental disorders, in a study of nearly 2 million births in Taiwan. The study found a 30% higher adjusted hazard for children born to mothers with SARDs compared to those without.
Background
Understanding the impact of maternal health on child development is crucial, particularly in the context of autoimmune diseases. Maternal SARDs encompass a range of conditions that may influence offspring health outcomes.
Data Highlights
| Group | Child Mental Disorder Diagnoses |
|---|---|
| Mothers with SARDs | 774 (20%) |
| Mothers without SARDs | 306,907 (16%) |
Key Findings
- Maternal SARDs were associated with a 30% higher adjusted hazard of childhood mental disorders.
- 20% of children born to mothers with SARDs were diagnosed with mental disorders.
- Higher hazards were noted particularly for offspring of mothers with systemic lupus erythematosus and primary Sjogren’s syndrome.
- Associations with anxiety disorders and neurodevelopmental disorders were observed, including ADHD and intellectual disabilities.
- No significant association was found between maternal SARDs and autism spectrum disorder.
- Low birth weight was identified as a partial mediator of the association between maternal SARDs and childhood mental disorders.
Clinical Implications
Healthcare providers should consider the potential impact of maternal SARDs on child mental health when assessing pediatric patients.
Conclusion
The study highlights the implications of maternal autoimmune conditions on child mental health.
Related Resources & Content
- Huang Y-C et al., Lupus Science & Medicine, 2023 -- Maternal systemic autoimmune rheumatic diseases and childhood mental disorders: a nationwide cohort study
- MDSpire News — Child Neurodevelopment After SARS-CoV-2 Exposure
- Frontiers in Psychiatry — Postnatal maternal mental health-related hospitalisation and its association with adverse child health and maltreatment outcomes: narrative review
- MDSpire News — Migraine in Parents May Implicate MMD Risk in Offspring
- MDSpire News — MS Linked to Higher Peripartum Depression
- Child Neurodevelopment After SARS-CoV-2 Exposure
- Postnatal maternal mental health-related hospitalisation and its association with adverse child health and maltreatment outcomes: narrative review
- Migraine in Parents May Implicate MMD Risk in Offspring
- [PDF] Maternal systemic autoimmune rheumatic diseases and childhood mental disorders: a nationwide cohort study | CiteDrive
- Association of Maternal Autoimmune Diseases With Risk of Mental Disorders in Offspring in Denmark - PMC
- Associations of prenatal exposure to maternal autoimmune disorders with a wide spectrum of psychiatric and neurodevelopmental disorders in offspring—a nationwide cohort study - PMC
- Maternal immune-mediated conditions and ADHD risk in offspring - PMC
- EULAR recommendations for use of antirheumatic drugs in reproduction, pregnancy, and lactation: 2024 update - PubMed
- EULAR recommendations for women's health and the management of family planning, assisted reproduction, pregnancy and menopause in patients with systemic lupus erythematosus and/or antiphospholipid syndrome - ScienceDirect
- Indications for Outpatient Antenatal Fetal Surveillance | ACOG
- Parental autoimmune and autoinflammatory disorders as multiple risk factors for common neurodevelopmental disorders in offspring: a systematic review and meta-analysis - PMC
- Recommendations for the Use of Disease-Modifying Antirheumatic Drugs in Pregnancy and Reproductive Health for Patients With Rheumatic Disease: A Scoping Review - PubMed
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