5 Key Takeaways

• 1

  A prospective, single-center study included 74 children with SLE and 112 age-matched healthy controls.

• 2

  IG percentage distinguished active SLE from remission with an area under the curve of 0.90, comparable to 0.92 for ESR.

• 3

  At an IG percentage cutoff greater than 0.35%, sensitivity was 81%, specificity was 87%, and diagnostic accuracy was 84%.

• 4

  IG percentage correlated moderately with SLEDAI-2K, clinical SLEDAI-2K, and physician global assessment, while complement C3 showed stronger correlations with disease activity.

• 5

  The authors described WBC inflammatory parameters as complementary measures and noted that small sample size, single-center design, and lack of independent validation limited the study.