JIA risk may be linked to pregnancy factors
Overview
Higher gestational weight gain and maternal hypertensive disorders may increase the risk of juvenile idiopathic arthritis (JIA) in offspring. A study involving 78,901 children found significant associations between these maternal factors and the development of JIA.
Background
Understanding the risk factors for juvenile idiopathic arthritis (JIA) is crucial for early identification. Maternal health during pregnancy, including weight gain and hypertensive disorders, may play a role in the risk of JIA in children. This study contributes to the literature examining the impact of prenatal factors on health outcomes in offspring.
Data Highlights
| Factor | Adjusted Odds Ratio (AOR) |
|---|---|
| Gestational weight gain (1 SD increase) | 1.12 |
| Maternal hypertension | 1.43 |
| Preeclampsia | 1.61 |
Key Findings
- Each 1-SD increase in gestational weight gain was associated with a 12% higher odds of JIA.
- Maternal hypertension was linked to a 43% increase in adjusted odds of JIA.
- Preeclampsia was associated with a 61% increase in odds of JIA.
- Maternal prepregnancy BMI was not found to be associated with JIA.
- Higher gestational weight gain was linked to increased odds of JIA in female offspring but not in males.
- Exploratory analyses suggested maternal overweight may lower odds of JIA in children with low or average genetic susceptibility.
Clinical Implications
The findings indicate associations between maternal weight gain and hypertensive disorders during pregnancy and the risk of JIA in children.
Conclusion
This study identifies potential associations between maternal pregnancy factors and the risk of juvenile idiopathic arthritis.
Related Resources & Content
- Dåstøl VØ et al., RMD Open, 2023 -- Maternal weight and hypertension as risk factors for juvenile idiopathic arthritis: a prospective population-based pregnancy cohort study.
- MDSpire News, 2023 -- Does JIA Increase Arthritis Risk?
- Clinical Rheumatology, 2025 -- A Structured Approach to Managing Pregnancy in Individuals with Inflammatory Arthritis.
- MDSpire News, 2023 -- Fish Intake Linked to JIA?
- American College of Rheumatology, 2026 -- ACR Releases Updated Juvenile Idiopathic Arthritis Guidelines.
- Clinical Rheumatology — Pregnancy Outcomes, Fertility, and Disease Activity in Juvenile Idiopathic Arthritis Patients: A Descriptive Analysis
- Maternal weight and hypertension as risk factors for juvenile idiopathic arthritis: a prospective population-based pregnancy cohort study.
- EULAR 2025 Abstract Review.
- ACR Releases Updated Juvenile Idiopathic Arthritis Guidelines | American College of Rheumatology
- EULAR 2025 ● Abstract Review
- Environmental determinants of juvenile idiopathic arthritis: current evidence and future directions - ScienceDirect
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