5 Key Takeaways

• 1

  A preventive care strategy based on KDIGO recommendations reduced moderate to severe AKI after major surgery in the BigpAK-2 trial.

• 2

  Moderate to severe AKI occurred in 14% of the intervention group versus 22% in the control group, indicating a significant reduction.

• 3

  The preventive strategy included hemodynamic optimization and avoidance of nephrotoxic drugs, targeting specific clinical parameters.

• 4

  Implementation of the full preventive strategy was achieved in 47% of patients, increasing to 63% when strict glycemic control was excluded.

• 5

  The trial's findings suggest that supportive care can effectively reduce AKI risk in high-risk surgical patients, though broader adoption may be limited.