5 Key Takeaways

• 1

  TOFA reduced body weight and fat mass by an average of 18% in male mice without affecting food intake or lean mass.

• 2

  TOFA improved metabolic parameters, including fasting blood glucose, insulin levels, glucose tolerance, and insulin sensitivity.

• 3

  Increased energy expenditure of approximately 18% was observed in TOFA-treated mice, independent of increased physical activity.

• 4

  TOFA treatment resulted in lower liver triglycerides, cholesterol, and reduced hepatic steatosis and fibrosis in mice.

• 5

  Combination therapy with TOFA and incretin analogs led to greater weight loss and improved glucose control compared to monotherapy.