3 Topic Commentaries

TOFA may drive weight loss without reducing food intake

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  Anders M. Näär, PhD

  Metabolic biology and nutrition

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  University of California, Berkeley

  Body weight responds to two levers: taking in fewer calories, or spending more energy. GLP-1s work almost entirely on the first, so we went after the second.

  Source
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  Justin Y. Lee, PhD

  Metabolic biology

  •

  University of California, San Francisco

  TOFA appears to engage a coordinated metabolic response. It is not simply blocking lipid synthesis. It is also activating energy expenditure pathways that may help the body handle excess lipid and glucose more effectively.

  Source
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  Anders M. Näär, PhD

  Metabolic biology and nutrition

  •

  University of California, Berkeley

  In our combination experiments, TOFA worked additively or synergistically with the GLP-1 appetite suppressing drugs, so we view it as complementary rather than as a replacement.

  Source