Clinical Report: DOOR framework shows similar outcomes in skin infection trials
Overview
A retrospective study applying the DOOR framework found that omadacycline and linezolid produced similar outcomes in treating acute bacterial skin and skin structure infections among 1,347 participants from two trials. The DOOR analysis indicated no statistically significant differences in treatment outcomes between the two antibiotics.
Background
Acute bacterial skin and skin structure infections (ABSSSI) are common and can lead to significant morbidity. This study evaluates the effectiveness of omadacycline compared to linezolid using a patient-centered approach.
Data Highlights
| Trial | DOOR Probability (Omadacycline vs Linezolid) | 95% Confidence Interval |
|---|---|---|
| OASIS-1 | 50.6% | 47.4%-53.7% |
| OASIS-2 | 52.1% | 49.2%-55.0% |
Key Findings
- About 80% of patients in both trials achieved the most desirable DOOR outcome.
- The DOOR distribution between treatment arms was similar for both omadacycline and linezolid.
- Absence of clinical response, infectious complications, and nonfatal serious adverse events were uncommon.
- In OASIS-2, patients with diabetes had a 58.1% probability of a more desirable outcome with omadacycline.
- No significant treatment differences were found for any individual DOOR component.
Clinical Implications
The DOOR framework provides a method for evaluating treatment outcomes in ABSSSI.
Conclusion
The application of the DOOR framework in this study highlights the comparable effectiveness of omadacycline and linezolid in treating ABSSSI.
Related Resources & Content
- Open Forum Infectious Diseases, 2023 -- DOOR framework shows similar outcomes in skin infection trials
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- Omadacycline for the treatment of acute bacterial skin and skin structure infections: a systematic review and network meta-analysis
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