3 Topic Commentaries

Extended antiviral therapy may not improve long COVID

• 

  Harlan M. Krumholz, MD

  Cardiology; outcomes research

  •

  Yale School of Medicine

  We got an answer that, though disappointing, at least provides more information for us to continue the effort to try to help relieve suffering among these individuals.

  Source
• 

  Akiko Iwasaki, PhD

  Immunology/Immunobiology

  •

  Yale School of Medicine

  There are lots of reasons why a clinical trial fails, but it’s still important for us to be able to say that this particular regimen wasn’t effective when compared to a placebo.

  Source
• 

  Matthew Durstenfeld, MD, MAS

  Cardiology

  •

  University of California, San Francisco

  Our finding that Paxlovid treatment during acute infection is not associated with lower odds of long COVID surprised us, but it is consistent with two other rigorously conducted studies finding no difference in post-COVID conditions between 4 and 6 months after infection.

  Source