Objective:
To investigate the association of frailty in individuals with HIV with inflammatory proteins, bone health markers, and T-cell exhaustion.
Approach:
- Study Design: Cross-sectional study involving 120 participants with HIV from the HAILO study, assessing frailty using modified Fried criteria.
- Measurements: Plasma markers and T-cell phenotypes were measured to evaluate their relationships with frailty.
Key Findings:
- 19 of 75 plasma markers were significantly associated with frailty, many linked to NF-κB signaling and SASP.
- Individuals with frailty had lower proportions of naïve CD4 and CD8 T cells and higher proportions of CD4 T cells expressing TIGIT and PD-1.
- Osteoprotegerin (OPG) was strongly linked to T-cell phenotypes and bone health in frail participants, with OPG and tumor necrosis factor levels positively correlated with PD-1 expression and negatively correlated with the naïve CD4 T-cell phenotype.
Interpretation:
The study identifies a link between inflammation, T-cell activation, bone health, and frailty in people with HIV.
Limitations:
- Cross-sectional design does not establish causality.
- The cohort with frailty was relatively young and mostly had a Fried score of 3, limiting assessment of advanced frailty.
- Unclear relevance of findings to the general population.
Conclusion:
The data indicate a connection between inflammation, immune responses, and frailty in individuals with HIV.
Sources:
This content is an AI-generated, fully rewritten summary based on a published scholarly article. It does not reproduce the original text and is not a substitute for the original publication. Readers are encouraged to consult the source for full context, data, and methodology.
