5 Key Takeaways

• 1

  Frailty in individuals with HIV is linked to inflammatory proteins, bone health markers, and T-cell exhaustion.

• 2

  The study involved 120 participants with HIV, half of whom met frailty criteria based on modified Fried criteria.

• 3

  Nineteen of 75 plasma markers were significantly associated with frailty, particularly those related to NF-κB signaling.

• 4

  Participants with frailty exhibited lower naïve CD4 and CD8 T cells and higher PD-1 and TIGIT expression.

• 5

  Osteoprotegerin was the marker most strongly associated with T-cell phenotypes and frailty among participants.