Neonatal HSV-1 diversity greater between patients than within patients
Overview
A study found that herpes simplex virus type 1 (HSV-1) diversity is greater between newborns than within the same newborn. Minor-variant counts did not significantly differ by disease severity.
Background
Understanding the diversity of HSV-1 in neonates is crucial due to the potential severity of infections, which can lead to significant morbidity and mortality. The study highlights the genetic variability of HSV-1 among newborns.
Data Highlights
| Parameter | Findings |
|---|---|
| Samples Analyzed | 30 residual diagnostic samples from 10 newborns |
| Cultured Samples | 14 of 30 samples yielded viral cultures |
| Minor Variants | Counts did not differ significantly by disease severity |
| Survival in Mice | 0% to 50% survival depending on isolate |
Key Findings
- HSV-1 diversity was greater between newborns than within the same newborn.
- Minor-variant counts did not significantly differ between mild and severe disease cases.
- Samples that could be cultured had higher viral genome copy numbers (P < .0001).
- Direct patient samples that could not be cultured had significantly more minor variants.
- Survival rates in mice inoculated with isolates varied from 0% to 50% based on the isolate.
Clinical Implications
The findings indicate the need for further research into the genetic diversity of HSV-1 in neonatal infections.
Conclusion
This study emphasizes the importance of inter-patient variability in HSV-1 infections among neonates.
Related Resources & Content
- Passetti HA et al., The Journal of Infectious Diseases, 2023 -- Neonatal HSV-1 diversity greater between patients than within patients
- Infection — Prevalence and Clinical Implications of Herpes Simplex Virus Types 1 and 2 Reactivation in Adults with Mild to Moderate Community-Acquired Pneumonia: A Multicenter Cohort Investigation
- Infection — Identification of herpesviruses in cerebrospinal fluid of adults with suspected viral meningitis in Malawi
- Frontiers in Neurology — Clinical characteristics and prognostic analysis of patients with herpesvirus meningitis/encephalitis based on cerebrospinal fluid mNGS positivity
- Herpes Simplex | Red Book: 2024–2027 Report of the Committee on Infectious Diseases
- A Controlled Trial Comparing Vidarabine with Acyclovir in Neonatal Herpes Simplex Virus Infection
- Epidemiology of Herpes Simplex Virus in Infants Aged 0–42 Days: 2008–2024 | Pediatrics | American Academy of Pediatrics
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