5 Key Takeaways

• 1

  Human seminal fluid enhances mpox virus infection in primary human cells, increasing viral attachment and uptake.

• 2

  Seminal fluid from all tested donors increased mpox-positive cells in fibroblasts and keratinocytes.

• 3

  Both SEVI and SEM, semen-derived amyloid fibrils, increased mpox infection in a dose-dependent manner.

• 4

  SEVI enhanced infection across multiple mpox clades and other viruses like cowpox and camelpox.

• 5

  The study indicates that semen-derived fibrils may increase the efficiency of viral transmission and enhance infection.