5 Key Takeaways

• 1

  Albumin-adjusted calcium has significant limitations and remains widely used despite evidence against its reliability.

• 2

  Adjusted calcium is particularly unreliable in elderly, critically ill, and renally impaired patients.

• 3

  The editorial warns that universal use of albumin-adjusted calcium can lead to misdiagnosis of calcium disorders.

• 4

  The concept of 'corrected calcium' has faced challenges since the 1970s, yet it persists in clinical practice.

• 5

  The authors advocate for replacing albumin-adjusted calcium with ionised calcium as the preferred measurement.