5 Key Takeaways

• 1

  A combination of prostate-specific antigen density, mpMRI, and PSMA PET/CT may identify patients with adverse prostate cancer pathology.

• 2

  In a study of 413 patients, 60% exhibited adverse pathology at radical prostatectomy.

• 3

  The triple-positive profile showed 100% specificity and positive predictive value, but low sensitivity at 9%.

• 4

  The study suggests this profile could guide future studies on biopsy-sparing diagnostic pathways.

• 5

  The findings highlight the need for external validation before adopting these criteria in prospective studies.