Clinical Report: Oral Microbiome Richness Tied to CRS

Overview

This study investigates the association between oral microbiome richness and chronic rhinosinusitis (CRS) in a cohort of adults. Increased oral microbiome richness was linked to a higher prevalence of nonallergic CRS and impaired forced vital capacity.

Background

Chronic rhinosinusitis is a prevalent inflammatory condition affecting approximately 11% of adults globally. This study contributes to the evidence linking microbiome diversity to respiratory health outcomes.

Data Highlights

Gingival sampling was performed in 355 participants, with metagenomic sequencing successful for 335 samples. Key findings include:

Key Findings

• Increased oral microbiome richness was associated with chronic rhinosinusitis overall.
• The association was strongest among participants with nonallergic chronic rhinosinusitis.
• No consistent association was found between alpha diversity and asthma or forced expiratory volume in 1 second.
• 291 bacterial genera were detected, with unique genera identified in participants without asthma and chronic rhinosinusitis.
• Functional gene profiling revealed significant differences, with many genes unique to participants without asthma or chronic rhinosinusitis.

Clinical Implications

The findings indicate an association between oral microbiome richness and nonallergic chronic rhinosinusitis.

Conclusion

The study highlights the association between oral microbiome richness and chronic rhinosinusitis.

Related Resources & Content

1. Frontiers in Immunology, 2026 -- Beyond dysbiosis: microbial metabolites as key remodelers of nasal mucosal immune tolerance in chronic rhinosinusitis
2. MDSpire News -- Side Effects: The Hidden Variable
3. Journal of Gastroenterology -- Endoscopic Brush Sample Analysis Reveals Mucosal Dysbiosis in Patients with Inflammatory Bowel Disease
4. CPG: Adult Sinusitis Update - American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNS)
5. Journal of Crohn's and Colitis — Specific Bacterial Co-abundance Groups Are Associated With Inflammatory Status in Patients With Ulcerative Colitis
6. EUFOREA/EPOS2020 statement on the clinical considerations for chronic rhinosinusitis with nasal polyps care
7. Efficacy and safety of dupilumab in patients with severe chronic rhinosinusitis with nasal polyps
8. CPG: Adult Sinusitis Update - American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNS)
9. Mepolizumab for chronic rhinosinusitis with nasal polyps (SYNAPSE): a randomised, double-blind, placebo-controlled, phase 3 trial - PubMed
10. Efficacy and safety of omalizumab in nasal polyposis: 2 randomized phase 3 trials - PubMed
11. Tezepelumab in Adults with Severe Chronic Rhinosinusitis with Nasal Polyps | New England Journal of Medicine
12. Role of oral bacteria composition and functional gene profiles in respiratory diseases
13. Variability of the Microbiota in Chronic Rhinosinusitis: A Scoping Review - PubMed
14. Effects of Probiotic Supplementation during Chronic Rhinosinusitis on the Microbiome