Objective:
To investigate the association between oral microbiome richness and chronic rhinosinusitis (CRS) in adults.
Approach:
- Study Design: Cross-sectional analysis of adults from the European Community Respiratory Health Survey across three centers.
- Participants: Gingival sampling was performed on 355 participants, with metagenomic sequencing successful for 335 samples.
- Outcomes Measured: Respiratory outcomes included asthma, chronic rhinosinusitis, sensitization status, spirometry, and fractional exhaled nitric oxide.
- Statistical Analysis: Adjusted analyses were conducted to assess associations between oral microbiome richness and respiratory outcomes.
Key Findings:
- Increased oral microbiome richness was associated with chronic rhinosinusitis overall.
- The association was strongest among participants with nonallergic chronic rhinosinusitis.
- No consistent association was found between alpha diversity and asthma or other respiratory outcomes.
- Functional gene profiling revealed broader differences in gene presence between groups.
Interpretation:
Increased oral microbiome richness correlates with nonallergic chronic rhinosinusitis and impaired forced vital capacity.
Limitations:
- Cross-sectional design limits causality conclusions.
- Cohort was enriched for respiratory symptoms and not representative of the general population.
- Recent antibiotic-use data were unavailable, and outcomes were based on questionnaire responses.
Conclusion:
Increased oral microbiome richness is associated with nonallergic chronic rhinosinusitis and impaired forced vital capacity.
Sources:
This content is an AI-generated, fully rewritten summary based on a published scholarly article. It does not reproduce the original text and is not a substitute for the original publication. Readers are encouraged to consult the source for full context, data, and methodology.
