Objective:

To evaluate the persistence of physical and psychosocial sequelae in adults following mpox infection, specifically focusing on the population of 154 adults from New York City and Houston.

Key Findings:

• 58% of participants had at least one persistent physical sequela.
• Most common sequelae were appearance-related, including skin discoloration (83%) and scarring (51%).
• 13% reported functional complications, primarily anorectal and urinary symptoms.
• 45% experienced increased depressive symptoms and 40% increased anhedonia.
• Persistent sequelae linked to more severe acute disease, specifically confluent lesions.

Interpretation:

Post-mpox sequelae frequently persist long-term, impacting both physical appearance and psychosocial well-being, highlighting the need for ongoing healthcare support.

Limitations:

• Study limited to participants from specific clinics in New York City and Houston, which may affect generalizability.
• Potential biases in self-reported health and psychosocial assessments.

Conclusion:

Long-term follow-up after mpox is essential to address persistent sequelae and their social and sexual impacts, including specific assessments for skin changes and functional complications.

Sources:

• Annals of Internal Medicine